Causal Genetic Variants in Stillbirth
نویسندگان
چکیده
منابع مشابه
Assigning a causal role to genetic variants in hypertrophic cardiomyopathy.
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MOTIVATION Increasingly, cost-effective high-throughput DNA sequencing technologies are being utilized to sequence human pedigrees to elucidate the genetic cause of a wide variety of human diseases. While numerous tools exist for variant prioritization within a single genome, the ability to concurrently analyze variants within pedigrees remains a challenge, especially should there be no prior i...
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BACKGROUND Mendelian randomization uses genetic variants, assumed to be instrumental variables for a particular exposure, to estimate the causal effect of that exposure on an outcome. If the instrumental variable criteria are satisfied, the resulting estimator is consistent even in the presence of unmeasured confounding and reverse causation. METHODS We extend the Mendelian randomization para...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2020
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa1908753